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To order Elliotts B^® Solution Please call
1-855-752-9317

National Drug Code	55792-007-10
Cardinal Health CIN Number	4888046
Amerisource Bergen Item Code	10125710
McKesson Corp Item Number	2022895

• Indication: Diluent for intrathecal administration of methotrexate sodium and cytarabine for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma
• Approval Date: FDA Approval — September 27, 1996
• How Supplied: 10 mL single-use ampules, packaged 10 amps per box and 20 boxes per case
• National Drug Code: 55792-007-10
• Shelf-life: 60 months from date of manufacture
• Storage: Store at controlled room temperature, 20°-25°C (68°C -77°F)
• A prescription product, available via any licensed pharmaceutical supplier or direct from Lukare Medical, LLC. Please see the chart on the left for the Big 3 wholesalers item numbers

What is the stability of methotrexate and cytarabine in Elliotts B® Solution?
Methotrexate Sodium and Cytarabine reconstituted in Elliotts B® Solution and stored in glass vials with plastic syringes have demonstrated to be physically and chemically stable for at least 48 hours at both 4°C and 23°C.
 
However, intrathecal administration of such admixtures should be completed within several hours of preparation, as Elliotts B® Solution does not contain any bacteriostatic preservatives and introduction of contaminated solutions into the
cerebrospinal fluid may have extremely serious consequences.
Are there any special instructions to draw the solution from the ampoule?
Intrathecal drug products should be inspected visually for particulate matter and discoloration prior to administration. A sterile filter-needle should be used to withdraw the contents of the ampule. A 5 micron needle is sufficient to filter out any glass particles.

Can Elliotts B® Solution be used with other intrathecal agents?
Elliotts B® Solution is an FDA approved diluent for the intrathecal administration of methotrexate sodium. Elliotts B® Solution is also indicated as a diluent for intrathecal cytarabine, both for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma. While there are ongoing studies other agents, Elliotts B® solution is FDA approved as a diluent for use with methotrexate sodium and with cytarabine. Any other use of Elliotts B® Solution is experimental, and all caution must be kept to ensure proper use of the product.
Is Elliotts B® Solution a buffering agent?
Elliotts B® Solution is a buffered salt solution for use as a diluent. The approximate buffer capacity of Elliotts B® Solution is 1.1 x 10^-2 equivalents when the challenge solution is 0.01 N HCL and 7.8 x 10^-3 equivalents when the challenge solution is 0.01 N NaOH. Elliotts B® Solution was more resistant to change induced by acid or base than other diluents.¹
Many products claim to be artificial CSF. Is Elliotts B® Solution Artificial human cerebral spinal fluid (CSF)?
Elliotts B® Solution is the only FDA approved diluent for the administration of methotrexate sodium and cytarabine. Elliotts B® Solution is not artificial CSF. While it matches CSF in glucose, osmolarity, pH, electrolyte contents etc. Elliotts B® Solution lacks the proteins present in human CSF, so it cannot be classified as artificial CSF.
What side effects can be expected with Elliotts B® Solution?
Adverse reactions may occur with any intrathecal administration and may be due to the chemotherapy or technique of intrathecal administration. Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. The labeling for methotrexate sodium and cytarabine should be consulted.
How is Elliotts B® Solution Stored?
Elliotts B® Solution should only be used if the solution is clear and the ampoule is intact. Elliotts B® Solution should be stored at temperatures between 20° – 25°C (68° – 77°F). Any unused portion should be discarded.
What is the recommendation for Usage in Pregnancy?
All components of Elliotts B® Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B® Solution.
How long has Elliotts B® Solution been on the market?
Elliotts B® Solution received FDA Approval in September 1996. Elliotts B® Solution has been used by hospitals throughout the US for decades.
How Do I order Elliotts B® Solution?
Elliotts B® Solution is available via the three major wholesalers (Cardinal Health, AmerisourceBergen and McKesson). You can also purchase Elliotts B® Solution directly from Lukare Medical, LLC. Please contact our Customer Service at 855-752-9317.

Literature List:

Cancer Facts & Figures 1996. Atlanta, GA: American Cancer Society, Inc.; 1996.

Cradock JC, et al. Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytarabine and hydrocortisone.

Miller BA, Ries LAG, Hankey BF et al (eds). Cancer Statistics Review: 1973-1990. Bethesda, MD: National Cancer Institute; 1993. National Institutes of Health publication 93-2789.

Geiser CF, Bioshop Y, Jaffe N. Furman L, Traggis D, Frie E. Adverse effects of intrathecal methotrexate in children with acute leukemia in remission. Blood. 1975;45 (2): 189-195.

See monograph reference list for additional references.

WARNINGS: Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer Methotrexate Sodium and Cytarabine agents. The labeling for methotrexate sodium and cytarabine should be consulted.