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Since Safety is a Concern… Elliotts B® Solution

Elliotts B® Solution

(Buffered Intrathecal Electrolyte/Dextrose Solution)

Cirle

Since Safety is a Concern… Elliotts B® Solution

Elliotts B® Solution

(Buffered Intrathecal Electrolyte/Dextrose Solution)

Cirle

Since Safety is a Concern… Elliotts B® Solution

Elliotts B® Solution

(Buffered Intrathecal Electrolyte/Dextrose Solution)

Cirle

Clinical Data

Rediscover Elliotts B® Solution

The efficacy of Elliotts B® solution as a diluent for intrathecal administration of methotrexate sodium and cytarabine is based on its buffering capacity which helps adjust the pH of these agents. In addition, data demonstrate that methotrexate sodium and cytarabine are stable in Elliotts B Solution for at least 10 hours at 25° C. No precipitation was observed.1

Craddock et al at NCI showed that when physiologic saline was used to dilute methotrexate, the pH of the solution was as high as 8.5. When used to dilute cytarabine, the pH of the resulting solution was an unphysiological 5.3. On the other hand, when either was diluted in Elliotts B Solution, the pH was held in the more physiologic range of 7.3-7.8.2 Geiser et al found a significant decrease in chemical arachnoiditis if methotrexate was diluted in Elliotts B Solution and compared to saline: 13% to 61%.3 As a result of that study, NCI made Elliotts B Solution available to pediatric cooperative cancer study groups and major cancer centers where it is estimated that more than 95% of all children with leukemia were treated on NCI protocols between 1975 and 1992.

1Zhang et al. Physical and Chemical Stability of Methotrexate Sodium, Cytarabine and Hydrocortisone Sodium Succinate in Elliott’s B Solution. Hospital Pharmacy, 1996, Vol 31(8).

2Craddock JC, et al. Evaluation of Some Pharmaceutical Aspects of Intrathecal Methotrexate Sodium, Cytarabine and Hydrocortisone Sodium Succinate. American Journal of Hospital Pharmacy, 1978, Vol 35(4):402-406.

3Geiser CF, et al. Adverse Effects of Intrathecal Methotrexate in Children with Acute Leukemia in Remission. Blood, 1975, Vol 45(2):189-195.

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Capsule

Elliotts B® Solution

(buffered intrathecal electrolyte/dextrose injection)

Elliotts B® Solution is a sterile, nonpyrogenic, isotonic solution containing no bacteriostatic preservatives. Elliotts B Solution is a diluent for intrathecal administration of methotrexate sodium and cytarabine.

Each 10 mL of Elliotts B Solution contains:

Sodium Chloride, USP 73 mg
Sodium Bicarbonate, USP 19 mg
Dextrose, USP  8 mg
Magnesium Sulfate • 7H2O, USP 3 mg
Potassium Chloride, USP 3 mg
Calcium Chloride • 2H2O, USP 2 mg
Sodium Phosphate, dibasic • 7H2O, USP 2 mg
Water for Injection, USP qs 10 mL

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Information Request

Elliotts B® Solution

For more information or questions of a medical nature,

please call 1-855-752-9317.

Or please e-mail: info@LukareMedical.com

To order Elliotts B® Solution, please call: 855-752-9317 or order via your wholesaler:

National Drug Code 55792-007-10
Cardinal Health CIN Number 4888046
Amerisource Bergen Item Code 10125710
McKesson Corp Item Number 2022895
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What is the stability of methotrexate and cytarabine in
Elliotts B® Solution?

Methotrexate Sodium and Cytarabine reconstituted in Elliotts B® Solution and stored in glass vials with plastic syringes have demonstrated to be physically and chemically stable for at least 48 hours at both 4°C and 23°C.
However, intrathecal administration of such admixtures should be completed within several hours of preparation, as Elliotts B® Solution does not contain any bacteriostatic preservatives. (Data on file)

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WARNINGS: Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer Methotrexate Sodium and Cytarabine agents. The labeling for methotrexate sodium and cytarabine should be consulted.

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