Clinical Data

Rediscover Elliotts B® Solution

The efficacy of Elliotts B® Solution as a diluent for the intrathecal administration of chemotherapeutics is based on its ability to act as a buffer and to raise the pH of chemotherapeutics at acid pH (e.g. cytarabine) and to lower the pH of chemotherapeutics at basic pH (e.g. methotrexate). In addition, data demonstrate that methotrexate sodium and cytarabine are stable in Elliotts B® Solution. (Cradock JC, et al. Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium,cytarabine and hydrocortisone sodium succinate. American Journal of Hospital Pharmacy (1978); 35:40)

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Elliotts B® Solution

(buffered intrathecal electrolyte/dextrose injection)

Elliotts B® Solution is a sterile, nonpyrogenic, isotonic solution containing no bacteriostatic preservatives. Elliotts B Solution is a diluent for intrathecal administration of methotrexate sodium and cytarabine.

Each 10 mL of Elliotts B Solution contains:

Sodium Chloride, USP 73 mg
Sodium Bicarbonate, USP 19 mg
Dextrose, USP  8 mg
Magnesium Sulfate • 7H2O, USP 3 mg
Potassium Chloride, USP 3 mg
Calcium Chloride • 2H2O, USP 2 mg
Sodium Phosphate, dibasic • 7H2O, USP 2 mg
Water for Injection, USP qs 10 mL

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Elliotts B® Solution

For more information or questions of a medical nature,

please call 1-855-752-9317.

Or please e-mail: info@LukareMedical.com

To order Elliotts B® Solution, please call: 855-752-9317 or order via your wholesaler:

National Drug Code 55792-007-10
Cardinal Health CIN Number 4888046
Amerisource Bergen Item Code 10125710
McKesson Corp Item Number 2022895
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What is the stability of methotrexate and cytarabine in
Elliotts B® Solution?

Methotrexate Sodium and Cytarabine reconstituted in Elliotts B® Solution and stored in glass vials with plastic syringes have demonstrated to be physically and chemically stable for at least 48 hours at both 4°C and 23°C.
However, intrathecal administration of such admixtures should be completed within several hours of preparation, as Elliotts B® Solution does not contain any bacteriostatic preservatives. (Data on file)

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WARNINGS: Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer Methotrexate Sodium and Cytarabine agents. The labeling for methotrexate sodium and cytarabine should be consulted.