Since Safety is a Concern... Elliotts B® Solution


Frequently Asked Questions

  • Primary Indication: Diluent for intrathecal administration of methotrexate sodium and cytarabine for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma
  • Approval Date: FDA Approval -- September 27, 1996
  • How Supplied: 10 mL single-use ampules, packaged 10 amps per box and 20 boxes per case
  • National Drug Code: 55792-007-10
  • Shelf-life: 60 months from date of manufacture
  • Storage: Store at controlled room temperature, 20°-25°C (68°C -77°F)
  • Availability: By prescription from any licensed pharmaceutical supplier

What is the stability of methotrexate and cytarabine in Elliotts B® Solution?

Methotrexate 3mg/mL and Cytarabine 2mg/mL reconstituted in Elliotts B® Solution and stored in glass vials with plastic syringes have demonstrated to be physically and chemically stable for at least 48 hours at both 4°C and 23°C.
However, intrathecal administration of such admixtures should be completed within several hours of preparation, as Elliotts B® Solution does not contain any bacteriostatic preservatives. (Monograph Reference: Data on file)

How can I order Elliotts B® Solution?

Please call 1-855-752-9317 or fax 1-855-752-9318.

For email inquiries:

Literature List:
Cancer Facts & Figures 1996. Atlanta, GA: American Cancer Society, Inc.; 1996.

Miller BA, Ries LAG, Hankey BF et al (eds). Cancer Statistics Review: 1973-1990. Bethesda, MD: National Cancer Institute; 1993. National Institutes of Health publication 93-2789.

Geiser CF, Bioshop Y, Jaffe N. Furman L, Traggis D, Frie E. Adverse effects of intrathecal methotrexate in children with acute leukemia in remission. Blood. 1975;45 (2): 189-195.

See monograph reference list for additional references


WARNINGS:Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the
technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents.
The labeling for methotrexate sodium and cytarabine should be consulted.

The information in this website should not be used as a substitute for a consultation or visit with your physician or other healthcare professional.
Should you have any healthcare related questions, see your physician or other healthcare professional promptly. For further information about
indications and usage, contraindications, warnings, precautions, adverse reactions, and overdosage please see the doctor's prescribing information
or other referenses such as "Martinedale", "PDR", "BP" etc.