Rediscover Elliotts B® Solution
efficacy of Elliotts B® Solution as a diluent for the intrathecal administration of chemotherapeutics is based on its
ability to act as a buffer and to raise the pH of chemotherapeutics at acid pH (e.g. cytarabine) and to lower the pH of chemotherapeutics
at basic pH (e.g. methotrexate). In addition, data demonstrate that methotrexate, cytarabine, and hydrocortisone sodium succinate
are stable in Elliotts B Solution for at least 10 hours at 25 degrees C. No precipitation was observed.
et al at NCI showed that when physiologic saline was used to dilute methotrexate, the pH of the solution was as high as 8.5.
When used to dilute cytarabine, the pH of the resulting solution was an unphysiological 5.3. On the other hand, when either
was diluted in Elliotts B Solution, the pH was held in the more physiologic range of 7.2-7.8.
Geiser et al found
a significant decrease in chemical arachnoiditis if methotrexate were diluted in Elliotts B Solution and compared to saline:
13% to 61%. As a result of that study, NCI made Elliotts B Solution available to pediatric cooperative cancer study groups
and major cancer centers where it is estimated that more than 95% of all children with leukemia were treated on NCI protocols
between 1975 and 1992.